South Carolina Hotel Reservations
Hotels in Santee, SC
Set along Interstate 95, Santee is located in central South Carolina in Orangeburg County. Found in the Santee River Valley, Santee is set on the shores of Lake Marion. Outdoor enthusiasts may explore the 2,500-acre Santee State Park – ideal for hiking, birding, canoeing and kayaking.
Santee visitors may also shop through Santee Village Outlet Mall, or tee off at the Santee National Golf Course, Lake Marion Golf Course, and the Santee Cooper Country Club. There are many ways to enjoy a stay in Santee – visit soon and discover your new favorite area attraction.
Local Area Favorites
- 12 Civil War Sites in South Carolina
Cannon at Fort Sumter
As site of the first Secession and the Firing on Fort Sumter, South Carolina is chock-full of intriguing Civil War and American history.
- Best Things to Do in Charleston, SC
Explore the Holy City!
Check out the best things to do in Charleston, South Carolina, from Fort Sumter to the City Market to Holy City Brewing.
- Best Things to Do in Columbia
An unbeatable itinerary for your visit to Columbia, South Carolina – covering everything from museums and parks to events and more.
- Best Things To Do in Myrtle Beach
Second Avenue Pier
Check out these must-see oceanside restaurants, amusement parks, and sandy beaches during your visit to Myrtle Beach.
- Film Sets in South Carolina!
Boone Hall Plantation & Gardens
Check out some film sets in South Carolina from the background of The Big Chill to Forrest Gump and even Eastbound & Down.
- MiLB Teams in South Carolina
Minor League Action in SC
What better way to enjoy the summer sunshine than by taking in a ballgame? Check out the four MiLB teams in South Carolina.
- 25 Things To Do With Kids in SC!
Picnic at State Parks
Choose from 25 kid-friendly destinations in the Palmetto State when planning your upcoming South Carolina trip.
- 10 Annual South Carolina Festivals
Oyster Roast in Charleston
All across the Palmetto State, communities are celebrating with a variety of annual festivals. Check out some of South Carolina's top annual festivals and plan your visit today.
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